butabarbital will decrease the level or influence of sulfamethoxazole by impacting hepatic enzyme CYP2C9/10 metabolism. Small/Significance Unfamiliar.butabarbital will reduce the level or effect of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.butabarbital will lower the level or effect of alprazolam